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GMP Technician I, Upstream

The Hearth - Columbus, OH💼 Full-time🗓 2026-09-15 → 2026-09-25

Core

Execute upstream manufacturing operations for AAV-based gene therapy products in compliance with cGMP regulations.

Role type

Technician I, GMP Manufacturing (Upstream)

Builds

AAV-based gene therapy products

Domain

Biotechnology / Gene Therapy / Upstream Bioprocessing

Deliverable

production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work

Required skills

cell culture expansion, transfection, harvest, bioreactor operation, aseptic transfer, sampling, in-process testing, data documentation, deviation reporting

Preferred skills

cGMP manufacturing experience, upstream bioprocessing, biologics manufacturing, cell culture techniques, viral vector-based gene therapy processes

Technologies

bioreactors, centrifuges, filtration systems

Responsibilities

Execute upstream manufacturing operations including cell culture expansion, transfection, and harvest; Prepare and operate bioreactors, centrifuges, and filtration systems; Perform media and buffer preparation and aseptic transfers; Monitor critical process parameters and report deviations; Conduct sampling and in-process testing; Document all manufacturing activities accurately; Collaborate with QA/QC to resolve deviations; Participate in process improvement initiatives; Follow safety procedures and EHS guidelines.

Seniority

Entry-level Technician

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