Scientist / Senior Scientist, Structural Cell Biology
Core
Design and implement experimental approaches using electron and light microscopy to study CNS cell biology, genetic perturbations, and image analysis for brain aging and neurodegeneration research.
Role type
Senior IC structural cell biologist (CNS)
Builds
Production microscopy datasets and structural cell biology insights for Altos Labs' brain aging programs
Domain
Biotech / Structural Cell Biology / Neuroscience
Deliverable
production ML models | product features | dashboards & analysis | research
Required skills
Cell culture of iPSC-derived CNS cell types, genetic manipulation, light microscopy operation and image analysis, electron microscopy sample preparation, biochemistry, image segmentation and quantitation
Preferred skills
Confocal and structured illumination microscopy, terabyte-scale dataset management, Fiji/ImageJ, Arivis, Relion, cryoSPARC, MATLAB, R, Python
Technologies
Zen, Elements, Arivis, Napari, Fiji, Relion, cryoSPARC, MATLAB, R, Python
Responsibilities
Provide advanced cell culture and genetic manipulation of iPSC-derived CNS cell types; Design and implement all phases of light microscopy experimentation; Prepare samples for cryo-electron microscopy; Engage with cross-lab teams to bridge in vitro and in vivo models; Assist in analysis of microscope images using specialized software
Seniority
Senior, hands-on IC