Senior Director, Disease Biology
Core
Lead target discovery and preclinical development for the Alzheimer's Disease Initiative, building new teams and workflows to carry validated targets through hit-to-lead progression and IND enabling studies.
Role type
Senior Director, Disease Biology (Strategy & Team Building)
Builds
New target discovery and preclinical development teams and workflows for Alzheimer's disease drug candidates
Domain
Biotechnology / Neurodegenerative Disease / Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Target discovery strategy, Preclinical program management, Team building and mentoring, Cross-functional program leadership, CRO and external partner management, Portfolio prioritization
Preferred skills
Alzheimer's disease drug discovery experience, Animal model generation and validation (APOE4, TREM2), Computational biology and machine learning integration, High throughput biology partnership
Technologies
Causal modeling, Human genetic data analysis, 3D cellular models, In vivo and in vitro disease models
Responsibilities
Build a new team to carry validated targets through drug discovery into preclinical programs; Guide programs through lead optimization and generate proof of concept data; Lead target discovery translating genetic and functional genomics findings into therapeutic targets; Lead existing in vivo and in vitro discovery teams; Partner with computational teams to apply causal modeling and prioritize candidates; Align priorities across target discovery and preclinical teams; Manage CRO and external partner relationships; Represent discovery strategy in cross-functional reviews
Seniority
Senior Director, hands-on IC with strategic leadership