Manager, Quantitative Systems Pharmacology
Core
Develop and apply mechanistic quantitative systems pharmacology (QSP), PK/PD, and PBPK models to integrate preclinical and clinical data, supporting drug development decisions and translation from preclinical species to humans.
Role type
Senior IC quantitative pharmacology modeler (QSP/PK/PD)
Builds
Mechanistic mathematical models for drug disposition, pharmacological activity, and dose-response relationships
Domain
Biopharma / Quantitative Systems Pharmacology / Pharmacometrics
Deliverable
production ML models
Required skills
mechanistic mathematical modeling, QSP, PK/PD, PBPK, differential equation-based modeling, model calibration, parameter estimation, sensitivity analysis, uncertainty analysis, MATLAB/SimBiology, R, Python, preclinical/clinical data integration
Preferred skills
Generative AI tools for scientific literature synthesis, advanced digital tools for model-development workflows
Responsibilities
Develop and validate mechanistic models to characterize drug disposition and pharmacological activity; Perform simulation to support candidate selection, first-in-human dose selection, and dose-regimen optimization; Integrate diverse data sources (in vitro, in vivo, clinical, literature) to generate testable hypotheses; Collaborate with cross-functional teams to identify opportunities for quantitative modeling impact; Communicate modeling strategies, assumptions, and results to multidisciplinary teams and scientific leadership; Contribute quantitative analyses to regulatory documents.
Seniority
Senior, hands-on IC