Research Leader (DMPK), Cambridge, MA
Core
Lead DMPK strategy for drug discovery projects using an AI-first approach to deliver high-quality clinical candidates.
Role type
Senior DMPK Lead (Drug Discovery)
Builds
Drug candidates and AI-driven ADME/toxicology predictive models
Domain
Biotech / Pharmaceutical R&D / Drug Discovery
Deliverable
production ML models
Required skills
DMPK strategy design, quantitative pharmacology, biotransformation, PK modelling, ADME scaling, regulatory document authoring, cross-functional collaboration
Preferred skills
Peptide modalities, PK/PD modelling, machine learning techniques, Python, R
Technologies
Python, R
Responsibilities
Design stage-appropriate DMPK strategies with AI-first approach; Design screening cascade and mechanistic experiments; Integrate DMPK, PD and toxicological data for decision-making; Define Quantitative Pharmacology strategy; Optimize use of datasets for DMPK questions; Optimize molecule design based on physico-chemistry; Author DMPK sections of regulatory documents.
Seniority
Senior, hands-on IC
