Postdoctoral fellow (m/f/d) – KH-2026-4
Core
Develop and optimize biochemical approaches to generate defined RNAylated biomolecules and establish design principles for their controlled, reproducible, and scalable production as part of an ERC-funded project.
Role type
Postdoctoral fellow (research scientist)
Builds
RNAylated proteins and nucleic acid–protein conjugates for biological and therapeutic applications
Domain
Biomedical research / RNA biochemistry / Protein engineering
Required skills
recombinant protein production, protein purification, enzymology, RNA biochemistry, nucleic acid chemistry, protein engineering, in vitro transcription, RNA modification, chromatography, fluorescence assays, mass spectrometry, proteomics
Preferred skills
CRISPR-Cas experience, RNA delivery experience
Technologies
gel-based assays, fluorescence readouts, chromatography, Western blotting, mass spectrometry, proteomics
Responsibilities
Designing, cloning, expressing, and purifying RNAylation enzymes, protein tags, and target proteins; Developing and optimizing enzymatic RNAylation reactions; Engineering enzymes or protein modules to improve activity, specificity, solubility, stability, or yield; Preparing and testing modified nucleic acid substrates; Establishing modular conjugation and purification workflows; Characterizing products using biochemical and analytical approaches; Analysing data, preparing publications and presentations; Co-supervising students
Seniority
Postdoctoral (Ph.D. holder)