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Principal Deep Learning/AI Engineer, Bioinformatics

San Diego, San Diego County💼 Full-time🗓 2026-03-28 → 2026-08-07

Core

Inventing, implementing, and validating AI- and ML-driven bioinformatics methods to power Illumina's sequencing and analysis products for early disease detection and diagnosis.

Role type

Principal Deep Learning/AI Engineer (Bioinformatics)

Builds

AI/ML features embedded in Illumina sequencing and analysis software and pipelines

Domain

Genomics and multiomics (basecalling, variant calling, error modeling, QC, anomaly detection, methylation, single-cell, metagenomics, assembly, interpretation)

Deliverable

production ML models

Required skills

algorithm design, model development, benchmarking, production readiness, technical direction, mentorship, data strategy, architecture design, regulatory validation

Preferred skills

null

Technologies

null

Responsibilities

Design, prototype, and implement AI/ML methods for genomics and multiomics; Serve as technical authority for AI features from concept through production release; Lead a focused team to create and sustain ML/AI products; Define gold-standard datasets, evaluation metrics, and statistical validation approaches; Ensure models are reproducible, versioned, monitored, and robust in production; Drive data strategy including curation, labeling, augmentation, and bias analysis; Lead architecture and design reviews for AI components; Provide technical input for design controls and validation in regulated contexts

Seniority

Principal, hands-on IC with mentorship

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