Senior Scientist
Core
Senior Scientist leading oncology target discovery and validation for antibody drug conjugate (ADC) therapeutics.
Role type
Senior IC oncology scientist (drug discovery)
Builds
Novel drug targets and validated mechanisms of action for ADC payloads
Domain
Biopharmaceuticals / Oncology / Drug Discovery
Required skills
Cancer biology, Cell/Molecular biology, Molecular biology, Genetic perturbation technologies (CRISPR, siRNA/shRNA), Transcriptomic data analysis, In vitro assay design and execution, Biomarker identification, Mechanism of action analysis, AI tools for drug discovery
Preferred skills
Quantitative mechanistic cell-based assay design, High-content imaging, Bioinformatics, Automation technology deployment
Responsibilities
Design and conduct in vitro experiments to evaluate candidate drug targets and identify novel targets for ADC payloads, Identify and onboard disease models and evaluate pharmacologic effects of experimental compounds, Review literature and internal data to identify and validate new targets, Develop and analyze in vitro studies to assess target relevance to cancer-cell function, Integrate experimental findings to uncover biomarkers of drug response or resistance, Collaborate with diverse scientific teams to align research activities with project objectives
Seniority
Senior, hands-on IC
