Clinical Pharmacometrician
Core
Set and implement quantitative strategy for cell therapy products, translating cellular kinetics and exposure–response modeling into dose optimization and patient selection.
Role type
Senior IC clinical pharmacometrician (cell therapy)
Builds
Mechanistic and empirical models for population PK, PKPD, and exposure-response to support trial design and regulatory submissions
Domain
Biopharmaceuticals / Cell therapy / Pharmacometrics
Deliverable
production ML models
Required skills
Population PK, PKPD, exposure-response modeling, QSP, Bayesian/adaptive methods, regulatory strategy, dose selection, biomarker integration, AI/ML for pharmacometrics
Preferred skills
AI/ML in pharmacometrics, cell therapy platforms (CAR T, TCR, autologous, allogeneic), disease areas (hematology, oncology, immunology)
Technologies
NONMEM, Phoenix/NLME, R, SAS, Python, MATLAB
Responsibilities
Build MIDD across cell therapy portfolio; Partner with project teams to build population PK, PKPD, and exposure-response models; Develop mechanistic and empirical models; Ensure modeling strategies align with regulatory expectations; Monitor and adopt emerging methodologies; Advance leadership through speaking and publications
Seniority
Senior, hands-on IC