Principal Scientist, Chemical Development
Core
Lead small molecule process development and manufacturing for antibody-drug conjugates (ADCs) and radiopharmaceuticals to enable patient treatment.
Role type
Principal Scientist, Chemical Development (Senior IC)
Builds
Robust, scalable small molecule synthetic processes and APIs for clinical-stage oncology therapeutics
Domain
Biopharmaceuticals / Oncology / Small Molecule Synthesis
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
small molecule synthetic process development, tech transfer to CMOs, regulatory document authoring (IND/NDA), analytical data collection and review, cGMP/ICH guidelines knowledge, cost of goods reduction, complex molecule synthesis, troubleshooting manufacturing processes
Preferred skills
experience leading linker-payload programs, managing external manufacturing partners, discovery chemistry collaboration
Technologies
HPLC, LC-MS, NMR, GC-MS, automated synthesis platforms
Responsibilities
Provide technical leadership on at least one program while contributing hands-on at the bench; devise and evaluate alternative synthetic routes to reduce COGs and lead times; develop data packages for technical transfer to external CMOs; contribute to regulatory documents (IND, IMPD, NDA); collaborate with research and CMC teams on integrated CMC strategies; ensure compliance with regulatory guidelines and industry standards
Seniority
Principal, hands-on IC with strategic oversight
