Senior Bioinformatics Scientist
Core
Design, develop, and validate next-generation minimal residual disease (MRD) laboratory-developed tests (LDTs) using NGS-based oncology assays to provide clinically actionable diagnostics for cancer patients.
Role type
Senior IC bioinformatics scientist (clinical diagnostics)
Builds
Production-ready bioinformatics pipelines for MRD analysis, variant calling, and reporting for LDTs
Domain
Oncology diagnostics / Clinical genomics / NGS
Deliverable
production ML models
Required skills
NGS-based assay development, ctDNA biology, Python (production pipelines), design-controlled environment experience, analytical study design, background error modeling, regulatory compliance (CAP/CLIA/FDA)
Preferred skills
AWS (EC2, S3, Lambda), R, relational/non-relational databases, germline/somatic mutation processes
Technologies
Python, AWS, R, NGS platforms
Responsibilities
Contribute to bioinformatics strategy for MRD assay design and lifecycle management; Lead analytical studies to evaluate assay performance (accuracy, LOD, reproducibility); Develop and maintain scalable bioinformatics pipelines for MRD analysis; Ensure compliance with CAP/CLIA, FDA, and IVDR standards; Partner with wet-lab, clinical, QA, and software teams; Mentor junior scientists on assay development rigor
Seniority
Senior, hands-on IC
