Principal Scientist - Materials Science
Core
Lead a matrix team to define and implement solid form/particle design and characterization strategies for Pfizer's drug molecules, ranging from small molecules to peptides, to accelerate bringing best-in-class medicines to market.
Role type
Principal Scientist (Materials Science)
Builds
Solid form and particle characterization data for active pharmaceutical ingredients (API) and drug product intermediates (DPI)
Domain
Pharmaceutical R&D / Materials Science
Required skills
small molecule crystallization, solid-state characterization (XRD, spectroscopy, thermal analysis), regulatory submission drafting, data analysis, statistical concepts, computational modeling, mentoring
Preferred skills
computational approaches (HABIT, Materials Studio, Mercury, CosmoTherm, SimCU), powder characterization (microscopy, image analysis), surface property testing (IGC, EDX, AFM), predictive tool development
Technologies
X-ray powder diffraction, polarized light microscopy, IR/Raman spectroscopy, laser diffraction, differential scanning calorimetry, thermogravimetric analysis, NMR, Materials Studio, Mercury, CosmoTherm, SimCU, HABIT
Responsibilities
Lead multidisciplinary project teams to define final drug substance forms (salt/polymorph/hydrate) and physical attributes; crystallize and screen neutral molecules, salts, and co-crystals; conduct solid-state physical and chemical characterization; apply computational approaches to predict solid form and particle properties; oversee external partners' laboratory studies; coach and mentor laboratory scientists; draft regulatory submissions and support patenting; collaborate on drug development strategy.
Seniority
Principal, hands-on IC with mentorship
