Predoctoral Research Position linked to the project: Synthetic biology-based circuits to promote efficacy and survival of cardiac tissue engineered 3D constructs
Core
Develop synthetic biology-based circuits using the synNotch system to create immune-camouflage phenotypes in hiPSC-derived cardiac cells for 3D engineered tissue constructs.
Role type
PhD research position in synthetic biology and tissue engineering
Builds
3D engineered cardiac tissue constructs with active immune-camouflage capabilities
Domain
Regenerative medicine, synthetic biology, cardiac tissue engineering
Deliverable
research
Required skills
synthetic biology, synNotch system design, hiPSC culture and differentiation, cardiac cell biology, 3D tissue engineering
Preferred skills
immunology, spatially restricted cellular response engineering
Technologies
synNotch system, hiPSC-derived cardiac cells, 3D tissue constructs
Responsibilities
Design and implement synNotch circuits to confer immune-camouflage on cardiac cells; integrate these cells into 3D engineered tissue constructs; evaluate efficacy and survival of the engineered tissues
Seniority
Pre-doctoral researcher