Director, Quantitative Systems Pharmacology
Core
Lead the development of mechanistic QSP and QST models to integrate clinical pharmacology, digital medicine, and systems modeling for drug discovery and development.
Role type
Director, Quantitative Systems Pharmacology (MIDD Lead)
Builds
Mechanistic mathematical models of disease progression and drug action for decision-making from exploratory research through clinical development.
Domain
Pharmaceutical R&D, Respiratory/Immunology/Inflammation, Model-Informed Drug Development (MIDD)
Deliverable
production ML models
Required skills
mechanistic mathematical modeling, inverse problem modeling, scientific machine learning, statistical methodologies, clinical pharmacology, pharmacometrics, systems biology
Preferred skills
Hepatology, Respiratory, or Cardiometabolic disease domain expertise
Technologies
AIML, simulation tools, state-of-the-art mathematical tools
Responsibilities
Build and guide mathematical model development to understand disease and drug action; conduct simulations to assess trial design performance; define and execute coordinated scientific and technical strategies (3-24 months); collaborate with biologists, clinicians, and statisticians to inform R&D programs; implement best practices in clinical pharmacology modeling; represent the team on internal advisory boards and leadership teams.
Seniority
Director, strategic leadership with hands-on modeling