Staff / Senior Scientist, Assay Research
Core
Design, plan, and execute experiments to improve the efficiency, accuracy, and scalability of protein sequencing by expansion (ProSE) process; establish novel assay workflows and define requirements for new components like beads and surface chemistries.
Role type
Staff / Senior Scientist, Assay Research
Builds
Predictive proxy assays and mechanistic understanding of the ProSE sequencing process
Domain
Life sciences / Proteomics / Molecular biology
Required skills
Molecular biology, Biochemistry, Chemistry, Nucleic acid chemistry, Peptide chemistry, Multimodal characterization (fluorescence, flow cytometry, zeta potential), Experimental design, Data analysis
Preferred skills
Nanopore/single-molecule detection platforms, Statistical analysis of mixed-effects data, LC-MS, HPLC, Bead-based automation
Technologies
PCR-free sequencing, Single-cell assays, KingFisher, Hamilton, Confluence
Responsibilities
Design and execute experiments to optimize ProSE process efficiency and accuracy; Develop proxy assays to predict multi-cycle performance; Correlate assay findings to physical characteristics of the system; Propose and test novel analytical approaches for sample preparation and chemistry; Collaborate with Chemistry, Automation, and Bioinformatics teams; Manage and analyze data from molecular biology experiments.
Seniority
Staff / Senior Scientist
