Scientist / Senior Scientist, Library Prep
Core
Lead research on library preparation for a single-molecule protein sequencing platform (ProSE) to prepare DNA molecules for nanopore sequencing.
Role type
Senior Scientist, Library Prep & Method Development
Builds
Reproducible, high-efficiency DNA library prep methods for nanopore sequencing
Domain
Life Sciences / Single-molecule Proteome Sequencing / Nanopore Technology
Required skills
Library prep method development, Enzymatic DNA manipulation, Chemically modified nucleic acids handling, Systems thinking, First-principles reasoning, DNA characterization/QC, Technical leadership
Preferred skills
Nanopore sequencing, Automated liquid handling, Protein sequencing background, AI tools usage
Technologies
SnapGene, mFold, NUPACK, Hamilton, KingFisher
Responsibilities
Design and test new library prep approaches to maximize read count and efficiency; Develop on-bead preparation and clean-up methods for low-input material; Investigate yield-limiting artifacts and troubleshoot library characteristics; Feed requirements back into upstream construct design; Guide bench work of research associates and students.
Seniority
Senior, hands-on IC with technical leadership
