Post-doc Design and synthesis of Enzyme Inhibitors

## Role Overview Using your experience in small-molecule organic synthesis, you will design and synthesise new heterocyclic molecules that are able to inhibit PDE enzymes. You will synthesise, isolate and characterise novel drug-like molecules. Your compounds will be screened for enzyme inhibition, enabling the development of structure-activity relationships that guide the synthesis of additional compounds. The candidate will join a well-integrated, multidisciplinary team and work closely with colleagues who conduct Computer-Aided Drug Design (CADD) studies and biological screening. The results are expected to lead to publications in high-quality scientific journals, while also contributing to the specific goal of developing new medicines for Alzheimer’s disease. ## Responsibilities - Design and synthesis of new heterocyclic molecules that inhibit PDE enzymes. - Synthesise, isolate and characterise novel drug-like molecules. - Screen compounds for enzyme inhibition. - Develop structure-activity relationships. - Collaborate with colleagues in CADD studies and biological screening. - Contribute to the development of new medicines for Alzheimer’s disease. ## Requirements - Experience with modern organic synthesis, including heterocyclic chemistry, parallel chemistry and a wide variety of reaction types. - Experience in purification and chemical analysis to characterise new small-molecule drug-like compounds (1D-NMR, 2D-NMR, LC-MS, HR-MS, IR, etc.). - Good communicative skills in writing and speaking and the ability to motivate and teach colleagues and undergraduate students. - An interest in medicinal chemistry and an understanding and willingness to be guided by the biological context. - The candidate is a team player who works together with colleagues who perform biological screening and perform CADD studies. ## Nice to Have - Recognised Researcher (R2) profile. ## Benefits A challenging position in a socially engaged organisation. A salary of minimum €3.546,00 (Scale 10) and maximum €5.538,00 (Scale 10) gross per month, on a full-time basis. A position for at least 0.8 FTE. An employment contract initially lasting 1 year. Attractive fringe benefits and regulations. A full-time 38-hour working week with holiday leave entitlement of 232 hours per year. 8% holiday allowance and 8.3% end-of-year bonus. Space for personal development. Access to sports facilities and discounts on theater performances and courses.