Post-doc Design and synthesis of Enzyme Inhibitors
Core
Design and synthesize new heterocyclic small-molecule inhibitors targeting PDE enzymes to develop treatments for Alzheimer's disease.
Role type
Post-doc medicinal chemist (organic synthesis)
Builds
Novel drug-like molecules and structure-activity relationships
Domain
Pharmaceutical research / Alzheimer's disease / Organic synthesis
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Heterocyclic chemistry, small-molecule organic synthesis, parallel chemistry, purification techniques, chemical analysis (NMR, LC-MS, HR-MS, IR), structure-activity relationship development
Preferred skills
Experience in medicinal chemistry, ability to guide undergraduate students, collaboration with CADD and biological screening teams
Technologies
1D-NMR, 2D-NMR, LC-MS, HR-MS, IR
Responsibilities
Design and synthesize new heterocyclic molecules that inhibit PDE enzymes, Synthesize, isolate and characterize novel drug-like molecules, Screen compounds for enzyme inhibition, Develop structure-activity relationships, Collaborate with colleagues in CADD studies and biological screening, Contribute to the development of new medicines for Alzheimer's disease
Seniority
Post-doc, hands-on IC
