Functional Interfaces and Predictive Signatures of Sarbecoviruses: From Intra-Host Evolution to Zoonotic Risks
Core
Characterize evolutionary dynamics of sarbecoviruses and virus-host interfaces using genomic, phylogenetic, and functional studies to identify signatures predictive of zoonotic transmission risks.
Role type
PhD researcher in virology and evolutionary biology
Builds
Evolutionary signatures and predictive models for interspecies coronavirus transmission
Domain
Virology, evolutionary biology, zoonotic risk assessment
Deliverable
research
Required skills
Genomic analysis, phylogenetic analysis, innate and adaptive immune response studies, virus-cell interaction experiments, molecular biology (PCR, RT-qPCR, cloning, mutagenesis, silencing, NGS library prep), cell culture (2D lines, explants, organoids), next-generation sequencing (metatranscriptomics, single-cell RNA sequencing), virology (isolation, cultivation, TCID50, transfection)
Preferred skills
Expertise in virology, microbiology, molecular biology, ecology, or biochemistry
Technologies
NGS, metatranscriptomics, single-cell RNA sequencing, BSL-3/BSL-2+ facilities
Responsibilities
Conduct longitudinal analysis of bat sarbecoviruses, perform functional studies on immune responses, execute controlled experiments on virus-cell interactions, identify evolutionary signatures and determinants of interspecies transmission
Seniority
PhD candidate (R1-R4) "lang": "en