CareerPlan

Senior Bioinformatics Engineer

US - California - San DiegoFull-time$129k–$194k2026-10-22 → 2026-11-10
HybridNo visa sponsorship

Core

Build and maintain the software platform that validates DRAGEN, Illumina's secondary analysis engine for clinical and research genomics, orchestrating automated tests across HPC clusters, AWS, and local nodes.

Role type

Senior Bioinformatics Software Engineer (Platform Engineering)

Builds

Scalable verification platform, plugin frameworks, workflow orchestration, CI/CD pipelines, and observability tools for 30+ engineering teams.

Domain

Genomics, Clinical Diagnostics, High-Performance Computing (HPC), Cloud Infrastructure

Deliverable

production ML models

Required skills

Python (Django, REST APIs, pytest), Software Architecture, System Design, CI/CD, Git/GitHub, Docker, Linux/Unix

Preferred skills

NGS/Secondary Analysis (variant calling, alignment), HPC/AWS workloads, Workflow Orchestration (Airflow, Nextflow), AI Coding Agents/LLM Integrations, Open-source contributions

Technologies

DRAGEN, AWS, HPC clusters, Django, pytest, Airflow, Nextflow

Responsibilities

Lead end-to-end verification for complex data analysis software; Partner with stakeholders to create automated verification workflows; Design and build scalable platform capabilities; Lead code reviews and champion engineering standards; Improve documentation, reproducibility, and developer productivity.

Seniority

Senior, hands-on IC with technical leadership