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Senior Engineer I/II, Drug Discovery Platform

Alewife, Cambridge, MA💼 Full-time💰 $148,000–$148,000🗓 2026-08-03 → 2026-09-27

Core

Build the data backbone for an AI-driven drug discovery factory, enabling a closed loop between computational design and wet-lab experiments.

Role type

Senior IC backend engineer (data platform)

Builds

Molecule queue, compound registration system, lab instrument data pipelines, synthesis constraints state, and observability infrastructure.

Domain

Biotech / Drug Discovery / Data Engineering

Deliverable

production ML models

Required skills

Python, SQL, relational and NoSQL database design, schema evolution, cloud infrastructure (AWS), containerized deployment (Kubernetes), AI-assisted development tools

Preferred skills

Cheminformatics (RDKit, OpenEye), compound registry systems, ELN/LIMS integration, workflow orchestration (Flyte, Airflow, Dagster), lakehouse patterns (Iceberg, Delta Lake), automation/robotics data capture, domain background in pharma/biotech, agentic/LLM workflows

Technologies

AWS, Kubernetes, Python, SQL, RDKit, OpenEye, Flyte, Airflow, Dagster, Temporal, Iceberg, Delta Lake, Hudi, DuckDB, Polars, Spark

Responsibilities

Design and operate the shared molecule queue broker; build canonical molecule registry with normalization and duplicate detection; ingest data from automated synthesis and QC instruments; maintain live synthesis constraints and inventory state; own data quality, lineage, and SLAs for the closed-loop cycle.

Seniority

Senior, hands-on IC

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