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Sr Principal/ Principal Software Engineer, AI Lab Execution System

Alewife, Cambridge, MA💼 Full-time💰 $204,000–$204,000🗓 2026-06-23 → 2026-07-31

Core

Architect and build the next-generation AI Lab Execution System connecting scientific intent, lab workflows, and AI-driven analysis for Lila Sciences.

Role type

Senior Principal Software Engineer (AI Lab Execution System)

Builds

High-performance APIs, user interfaces, data models, and reliability-critical systems integrating AI frameworks with scientific analytics.

Domain

Life sciences / AI / Laboratory automation

Deliverable

production ML models | product features | infrastructure

Required skills

TypeScript, React, Python, Systems and Data Architecture, SQL, NoSQL/Vector/Graph databases, API and Platform Design, Scientific or Data-Intensive Domains, Operational Excellence, Technical Leadership

Preferred skills

Orchestration Systems (Airflow, Prefect, Temporal, Dagster), Python for Science (pandas, numpy, scipy, jax, pytorch), Auditability and traceability systems

Technologies

AWS, Kubernetes, React, TypeScript, Python, SQL, NoSQL, Vector databases, Graph databases, Data lakehouses

Responsibilities

Define architectural direction for the AI Lab Execution System; Design systems modeling scientific intent and lab workflows; Lead design of high-performance UIs and APIs; Establish domain models and data contracts; Set standards for reliability, performance, and scale; Guide cloud infrastructure and DevOps practices; Mentor engineers and drive architecture reviews.

Seniority

Senior Principal, hands-on IC with strategy & mentorship

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