Structural Biology Research Scientist
Core
Design viral protein constructs, optimize expression systems, purify proteins, and perform cryo-EM studies to advance vaccine development.
Role type
Structural Biology Research Scientist
Builds
Viral protein constructs and cryo-EM data for vaccine development
Domain
Biotechnology / Structural Virology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Structural biology, viral protein construct design, expression system optimization, protein purification (chromatography), binding/antigenicity assays (ELISA, BLI, SPR), biochemical/biophysical characterization (SEC-MALS, DLS), cryo-EM sample preparation and vitrification, cryo-EM instrument operation
Preferred skills
NIH support experience
Technologies
Titan Krios, Glacios, SEC-MALS, DLS, ELISA, BLI, SPR
Responsibilities
Design and generate expression constructs for viral proteins; Develop and optimize expression systems (mammalian, insect, or stable cell lines); Purify proteins using chromatography methods; Perform binding and antigenicity assays; Conduct biochemical and biophysical characterization; Prepare samples and optimize vitrification conditions for cryo-EM studies; Operate and/or coordinate use of cryo-EM instruments; Prepare technical reports, figures, and manuscripts
Seniority
Mid-level Research Scientist
