Scientist I, Biotherapeutics Expression
Core
Engineering biologics in CHO cell lines, protein expression, and characterization to support therapeutic area drug discovery projects.
Role type
Scientist I, Biotherapeutics Expression (hands-on IC)
Builds
Stable CHO cell lines expressing novel multispecific biologics
Domain
Biopharmaceuticals / Biotherapeutics
Required skills
CHO cell line engineering, fed-batch bioreactor operation, shake flask expression, cell culture, cryopreservation, FACS-based single-cell sorting, ddPCR, vector design, process optimization
Preferred skills
Multispecific antibody development, automation platform implementation, data digitization, troubleshooting aggregation/glycosylation issues
Technologies
Wave bioreactors, ddPCR, FACS
Responsibilities
Generate and screen stable CHO cell lines; optimize fed-batch and shake flask expression processes; handle cell line thaw, culture, and cryopreservation; characterize copy number and mRNA levels; implement automation workflows; design and execute experiments
Seniority
Individual Contributor (IC), Scientist I