Scientist II
Core
Lead development and characterization of antibody brain shuttle compounds to optimize delivery of large-molecule therapeutics for neurodegenerative diseases.
Role type
Senior Scientist (In Vivo/In Vitro Characterization)
Builds
Modular brain delivery platform for CNS drugs
Domain
Neuroscience / Biopharmaceuticals
Required skills
cell culture, rodent handling, protein/antibody analytics, ELISA, western blotting, confocal imaging, FACS, SPR, BLI, SEC, in vivo PK/PD studies, tissue harvesting
Preferred skills
PhD in neuroscience/biology, industry experience, protein science analytics expertise
Technologies
SPR, BLI, SEC, ELISA, FACS, confocal microscopy
Responsibilities
Develop and validate protocols for cell-based assays and in vivo studies; Lead in vitro and in vivo validation of antibody shuttles; Engineer and optimize shuttles for specific therapeutic payloads; Mentor and train technicians and trainees; Perform biophysical characterization of antibodies.
Seniority
Senior, hands-on IC