Principal Research Scientist II, Computational Sciences, MPDD
Core
Lead computational chemistry initiatives to design and optimize drug candidates using physics-based simulations and AI/ML for AbbVie's drug discovery and development.
Role type
Principal Research Scientist II (Computational Sciences)
Builds
Hierarchical modeling approaches integrating physics-based atomistic methods with machine learning and AI for drug candidate design
Domain
Biopharmaceuticals / Computational Chemistry / AI & Machine Learning
Deliverable
production ML models
Required skills
Quantum mechanics, atomistic molecular simulations, molecular dynamics, machine learning, artificial intelligence, hybrid physics-informed AI/ML, drug discovery, medicinal chemistry, model benchmarking, cross-functional collaboration
Preferred skills
Mentoring early- and mid-career scientists, external partnership building, scientific communication, emerging technology identification
Technologies
Molecular dynamics, quantum mechanics, hybrid physics-informed AI/ML
Responsibilities
Establish quantitative objectives for lead optimization and de-risking; Provide scientific leadership in computational chemistry approaches; Guide team members in benchmarking studies; Lead development of internal computational models and workflows; Apply physics-based and AI/ML methods to support drug discovery; Collaborate with cross-functional partners to integrate computational tools; Present program updates and scientific recommendations; Build relationships with external collaborators.
Seniority
Principal, strategy & mentorship
