Senior Bioinformatics Engineer

## About the role At Sequencing.com, we're on a mission to make genomics understandable, actionable, and accessible to everyone. Our bioinformatics team powers the data analysis and interpretation that helps users uncover meaningful insights about their health, wellness, and ancestry from their DNA. We are seeking motivated and talented people to join our Bioinformatics team. Join us and help shape the future of personal genomics. We are seeking two Senior Bioinformatics Engineers to develop cutting-edge genomic analysis tools and infrastructure. This role requires expertise in cloud technologies, large-scale genomic data processing, and software development. ## Responsibilities - Design, build, and maintain scalable pipelines for processing and analyzing clinical‑grade 30x whole‑genome data, while supporting a wide range of genomic data types at consumer scale. - Optimize performance, reliability, and cost of data processing pipelines across AWS and hybrid environments, with a focus on high throughput and predictable latency for end users. - Develop production-quality services and tools using Python, C#, SQL, and AWS (e.g., Lambda, Glue, Batch, S3, RDS) that power Sequencing's DNA apps and reports. - Collaborate across product, science, engineering and UX teams to translate scientific findings into clear, consumer‑friendly genetic insights that are easy to navigate. - Establish and adhere to best practices for software engineering, data versioning, testing, observability, and documentation across bioinformatics workflows. ## Requirements - 5+ years of experience in bioinformatics, computational biology, computer science, or a related field. - Strong hands-on experience working with real-world genomic datasets and file formats such as VCF, BAM, and FASTQ. - Solid understanding of genomic databases, standards, and annotation resources. - Proficiency in Python, SQL, and C#, with a track record of writing clean, maintainable code. - Experience designing and implementing bioinformatics pipelines and data processing systems in production. - Experience building scalable, reliable systems on cloud platforms (e.g., AWS), including use of managed services. - Familiarity with containerization and orchestration technologies (e.g., Docker, Kubernetes). - Excellent problem-solving skills and a systematic approach to debugging complex data and infrastructure issues. - Exceptional attention to detail and commitment to high-quality, validated output. - Demonstrated experience operating and improving production systems where correctness and reliability are critical. - Ability to effectively leverage AI tools to increase productivity, code quality, and testing depth. - Fluency in English, both written and verbal, with the ability to communicate clearly with technical and non-technical stakeholders. ## Nice to have - Location: Remote: This position is not open to candidates residing in New York City. ## What we offer - Proudly named GenomeWeb's Best Place to Work in 2024, Sequencing is venture-backed and scaling rapidly to meet surging demand in the fast-growing personal genomics market. - We're a fully remote, global team of innovators, scientists, and builders, united by a mission to make genomics accessible, actionable, and life-changing for everyone. ## About the company Sequencing is powering the future of personalized health. We are the platform that transforms a person's genome into a lifelong source of straightforward, actionable insights - for individuals, families, and healthcare professionals. By providing the application layer to your DNA, we turn complex genetic data into recurring value throughout every stage of life. Our unique, clinical-grade Whole Genome Sequencing unlocks the most complete view of your DNA, screening for almost all known health conditions, traits, and medication responses - and translating that information into clear, actionable steps for managing health risks, optimizing wellness, and extending longevity. As whole genome sequencing becomes a standard part of life, Sequencing is already the trusted platform where people safely store their DNA data - and will become the lifelong home for every genome on Earth. If you're excited to help redefine how the world thinks about health, join us in building the platform that brings every genome to life. Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. Sequencing Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting [email protected].