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Sr. Principal Scientist, Amazon Health Science & Analytics

Santa Clara, California, United States💼 Full-time💰 $276,100–$350,000🗓 2025-11-27 → 2026-09-25

Core

Architect and guide a long-horizon ML strategy for a healthcare-focused organization, building a domain-specific foundation model and high-reliability inference system.

Role type

Sr. Principal Scientist (AI/ML Research & Strategy)

Builds

Proprietary domain healthcare models, high-reliability inference systems, and customer-facing features.

Domain

Healthcare / Large-scale AI/ML

Deliverable

production ML models

Required skills

Large-scale model training/adaptation (LLMs, multimodal, MoE), distributed training, RLHF/DPO, retrieval and knowledge integration, evaluation harness design, ML systems engineering, technical vision definition, safety architecture design, data strategy, cross-functional partnership.

Preferred skills

Healthcare/pharmaceuticals/biotechnology domain experience, clinical data familiarity, ISO-aligned safety practices.

Technologies

LLMs, multimodal models, MoE systems, distributed training frameworks, RLHF/DPO tools.

Responsibilities

Define technical vision for frontier model integration and capability sequencing, partner with product/engineering/clinical/compliance teams to ensure safety and reliability, advise on data strategy and evaluation frameworks.

Seniority

Principal, strategy & mentorship

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