Probing the methylome in cardiac remodelling in pathology and aging to discover biomarkers of health and mechanisms underlying transcriptional changes.
Role Overview:
Probing the methylome in cardiac remodelling in pathology and aging to discover biomarkers of health and mechanisms underlying transcriptional changes.
Responsibilities:
You will develop your own project on developing new pipelines for analysis of DNA in cardiac cells and using these to determine how DNA methylation changes and influences cardiac remodelling during aging and disease. You will collaborate with members of the Functional Epigenetics and Experimental Cardiology laboratories, as well as with national and international collaborators involved. You will be expected to develop expertise in areas necessary for successful progress of your project. You will be expected to present your work at conferences, lab meetings, and departmental meetings.
Requirements:
You are motivated, have an enquiring mind and are excited by science. You are experienced in NGS approaches, including RNA-Seq. Experience in single cell methods is also an advantage. Experience with NGS data processing and working knowledge of R, Python and bioconductor packages are a strong advantage. You have experience in cell biology and mouse models/experiments and are driven to establish mechanisms controlling cell function. You have a demonstrated ability to perform high-level biomedical research. You enjoy collaborating with your colleagues and externally to scientific advance. You hold a PhD degree in Biomedical Sciences, Cell Biology, Biochemistry or other similar domain of life sciences with working knowledge in relevant areas. You are a team player with excellent written and oral communication skills in English. You are an independent thinker who can drive a project forward. You enjoy presenting your data to collaborators and to the community at scientific meetings. You perform your research to the highest standards and integrity.
Qualifications:
PhD degree in Biomedical Sciences, Cell Biology, Biochemistry or other similar domain of life sciences with working knowledge in relevant areas. Experience in NGS approaches, including RNA-Seq. Experience in single cell methods is also an advantage. Experience with NGS data processing and working knowledge of R, Python and bioconductor packages are a strong advantage. Experience in cell biology and mouse models/experiments. Demonstrated ability to perform high-level biomedical research. Excellent written and oral communication skills in English.
What They Offer:
A fully funded PhD position for 4 years. A stimulating and supportive environment in which you acquire expertise as a multidisciplinary researcher. Opportunity to develop yourself as an independent researcher. Opportunity to collaborate nationally and across borders. Support to apply for independent funding from the national and international funding agencies including the Flemish Research Council (FWO) and the EU.