Scientist, Cell-Free Systems
Core
Build cell-free systems for non-model organisms and diverse biological systems to measure, control, and apply biology.
Role type
Senior IC scientist (cell-free systems & biochemistry)
Builds
Cell-free protein synthesis (CFPS) and coupled transcription-translation (TX-TL) systems for non-model organisms
Domain
Synthetic biology, biochemistry, chemical engineering
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
cell-free system development, protein purification, enzymology, reaction optimization, metabolic pathway reconstruction, analytical assay design, quantitative modeling, molecular biology
Preferred skills
non-model organism expertise, cell-free metabolic engineering, reaction/kinetic modeling, lab automation, high-throughput screening
Technologies
ÄKTA/FPLC, affinity chromatography, ion-exchange, size-exclusion, LC-MS, HPLC, Python, R, JMP
Responsibilities
Develop and optimize cell-free systems (crude-extract and reconstituted), establish robust lysate workflows, express/purify/characterize enzymes and cofactors, engineer energy and cofactor regeneration, reconstruct metabolic pathways in vitro, model and optimize reactions, build and run analytical assays
Seniority
Senior, hands-on IC
