LC-MS Chemist - Metabolism
Core
Perform routine to moderate-level method validation and execute advanced ADME/PK assays using LC-MS/MS to support drug metabolism studies.
Role type
Mid-level IC LC-MS chemist (metabolism/bioanalysis)
Builds
Bioanalytical data and validated methods for pharmaceutical clients
Domain
Life sciences / Bioanalysis / Drug metabolism
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
LC-MS/MS method execution, MRM-based quantitation, ADME/PK assay development, triple quadrupole mass spectrometer operation, GLP/GCP compliance, data interpretation, SOP adherence, project coordination, team mentoring
Preferred skills
CYP inhibition assay execution, Time-Dependent Inhibition (TDI) studies, drug-drug interaction (DDI) studies, bioanalytical method optimization, high-resolution mass spectrometry (Orbitrap) familiarity
Technologies
Waters Xevo TQS, Agilent 6400 QQQ, SCIEX 5500, SCIEX 6500, MassLynx, MassHunter, Analyst, ELN
Responsibilities
Organize and independently perform routine to moderate-level method validation activities; Execute advanced method validation tasks with guidance; Resolve procedural and scientific problems using analytical instrumentation skills; Review reports, methods, protocols, and SOPs; Manage assigned project work and coordinate with team members; Train and mentor less experienced laboratory staff
Seniority
Mid-level, hands-on IC