Principal Software Engineer - Variant Knowledge Platform
Core
Designing and operating the Variant Knowledge Platform, the authoritative source for variant identity, classification, and annotation to power clinical interpretation and analytics.
Role type
Principal Software Engineer (Backend/Platform)
Builds
Production-grade REST APIs, data models, and pipelines for variant data serving internal and enterprise clients.
Domain
Healthcare diagnostics, genomics, bioinformatics
Deliverable
production ML models | product features | infrastructure
Required skills
REST API design, cloud service architecture, backend programming, data modeling, system architecture, technical leadership, cross-functional collaboration
Preferred skills
Genomics/bioinformatics domain knowledge, event-driven architectures, regulated environment experience, multi-tenant system design, large-scale data migration
Technologies
AWS, Python, Okta, REST, Snowflake
Responsibilities
Own technical design for ambiguous problems, define and evolve data models, design production-grade REST APIs, lead system evolution for real-time multi-tenant operation, drive architecture for automation and scaling, define org-wide system architectures, lead cross-team technical programs, set strategy for system operability, lead large-scale data migration, mentor engineers, partner with cross-functional stakeholders
Seniority
Principal, hands-on IC with strategic leadership
