PhD Position (m/w/d)
Core
PhD researcher investigating how inflammatory and metabolic signals affect cardiomyocyte function, epigenetic state, and gene regulation using human stem cell models.
Role type
PhD researcher (molecular/cell biology)
Builds
Bioengineered 3D microenvironments and 2D models of human cardiomyocytes
Domain
Biomedical research / Cardiology / Molecular & Cell Biology
Deliverable
research
Required skills
Molecular cloning, CRISPR/Cas-based genome and transcription engineering, High-Content Imaging, Next-Generation Sequencing (RNA-Seq, ATAC-Seq, ChIP-Seq/CUT&Tag), Cell culture of mammalian cells, qPCR, Flow cytometry, ELISA, Immunoblotting
Preferred skills
hiPSC culture and differentiation, Cardiology, Immunology, Epigenetics, Bioengineering, Computational analysis of sequencing data
Technologies
CRISPR/Cas, shRNA, RNA-Seq, ATAC-Seq, ChIP-Seq, CUT&Tag, High-Content Microscopy
Responsibilities
Establish and optimize hiPSC-derived cardiomyocyte models in 2D and 3D bioengineered environments; Generate and analyze transcriptomic and epigenomic datasets; Link high-throughput sequencing data with imaging and functional phenotyping; Investigate signal and transcription regulators using genetic and pharmacological approaches; Document, analyze, and interpret experimental results; Present research at conferences and publish in peer-reviewed journals
Seniority
PhD Candidate