Principal Scientist, Biochemical and Cellular Pharmacology
Core
Lead the discovery and characterization of innovative therapeutic drug candidates, specifically focusing on G-protein coupled receptor (GPCR) pharmacology to inform target candidate profiles.
Role type
Principal Scientist, Biochemical and Cellular Pharmacology
Builds
Innovative therapeutic drug candidates for cardiovascular, renal, or metabolic disease fields
Domain
Biopharmaceuticals / GPCR Pharmacology
Required skills
GPCR pharmacology, receptor theory, signal transduction pathways, allosteric modulation, biased signaling, assay development, protein-protein interactions, biosensors, CRISPR, primary cell culture
Preferred skills
Cardiovascular/renal/metabolic disease expertise, advanced computational tools, mentoring
Technologies
cAMP, calcium flux, BRET/FRET, Beta-arrestin recruitment
Responsibilities
Provide strategic leadership as primary GPCR expert, oversee in vitro pharmacological characterization, design and implement complex molecular pharmacology assays, mentor Scientist partners, pioneer new technologies, communicate findings to stakeholders
Seniority
Principal, hands-on IC with strategic leadership