Scientist 3/4, Complex in Vitro Systems
Core
Develop, characterize, and qualify advanced human-relevant in vitro models (stem cell, iPSC, 3D, organoids) to support drug discovery and safety evaluation, with an emphasis on ocular applications.
Role type
Senior IC experimental scientist (stem cell biology & complex in vitro systems)
Builds
Human-relevant in vitro models for target assessment, drug discovery, and safety evaluation
Domain
Biopharmaceuticals / Stem Cell Biology / In Vitro Modeling
Required skills
mammalian cell culture, human stem cell/iPSC culture and differentiation, 3D culture/organoids/spheroids, functional and phenotypic assay development, qRT-PCR, transcriptomics, proteomics, immunofluorescence, confocal microscopy, high-content imaging, experimental design, troubleshooting, protocol optimization
Preferred skills
ocular/retinal biology, functional characterization of epithelial/endothelial systems, cell engineering, genome editing, automation/high-throughput workflows, design of experiments (DOE)
Technologies
qRT-PCR, transcriptomics, proteomics, immunofluorescence, confocal microscopy, live-cell imaging, high-content imaging
Responsibilities
Maintain and expand human stem cell and iPSC cultures including differentiation, maturation, cryopreservation, and phenotypic characterization; Design and execute experiments to establish reproducibility and biological relevance of complex in vitro models; Develop and apply functional and phenotypic assays; Support development of ocular complex in vitro models including retinal, RPE, vascular, and organoid systems; Apply rigorous experimental design and protocol optimization; Analyze and interpret multidimensional datasets; Collaborate with multidisciplinary teams to align model development with program needs; Maintain comprehensive electronic documentation and contribute to study reports and publications
Seniority
Senior, hands-on IC