Senior Principal Scientist, Pathologist
Core
Lead toxicologic pathologist providing scientific leadership for drug development safety assessment from discovery through marketed products.
Role type
Senior Principal Scientist (SE8), hands-on IC with strategic leadership
Builds
Safety assessment programs, regulatory documents, and strategic decisions for novel modalities
Domain
Pharmaceutical/Biotechnology, Translational Safety, Toxicologic Pathology
Required skills
toxicologic pathology, nonclinical safety assessment, regulatory toxicology, risk-based decision making, cross-functional leadership, scientific strategy, biomarker development, digital/computational pathology, 3Rs principles
Preferred skills
novel therapeutic modalities, NAMs, organotypic/in vitro models, computational/digital pathology, animal welfare commitment, multi-therapeutic area experience, health authority interactions, scientific thought leadership
Technologies
GLP/non-GLP study design, necropsy, histopathology, digital pathology tools, computational pathology approaches
Responsibilities
Lead pathology strategy for complex development programs; interpret nonclinical safety data and provide expert input; partner to design safety programs; synthesize datasets for risk assessment; design mechanistic studies; develop safety biomarkers and digital pathology approaches; refine study design to reduce animal use; author regulatory documents and represent company with health authorities; mentor scientists and lead cross-functional initiatives; advance external scientific standing through publications and collaborations
Seniority
Senior Principal, high autonomy, strategic influence, mentorship