Senior Principal Toxicologist-Scientist
Core
Lead toxicologist providing scientific leadership for safety assessment of Genentech therapeutics across drug development from discovery to marketed products.
Role type
Senior Principal Scientist (Toxicology)
Builds
Safety assessment strategies, GLP/non-GLP safety programs, regulatory documents, and weight-of-evidence syntheses for novel modalities and accelerated regulatory strategies.
Domain
Pharmaceutical/Biotechnology, Translational Safety, Toxicology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
[Toxicology expertise], [Drug development lifecycle knowledge], [Regulatory authority interaction], [Risk assessment], [Study design], [Data synthesis], [Strategic planning], [Cross-functional leadership], [Scientific publications], [Mentorship]
Preferred skills
[Small molecules experience], [Degraders experience], [ADCs experience], [Metabolite/impurity de-risking], [Novel therapeutic modalities], [Board certification in toxicology]
Technologies
[GLP study protocols], [NAMs (New Approach Methodologies)]
Responsibilities
[Lead toxicology for multiple complex development programs], [Design and implement safety assessment strategies], [Synthesize complex datasets for risk assessment], [Anticipate and investigate safety liabilities], [Author regulatory documents and present to health authorities], [Mentor toxicologists and lead cross-functional initiatives]
Seniority
Senior Principal, strategic leadership & mentorship
