Principal / Senior Principal Scientist- Investigative Toxicology
Core
Drive strategy, development, and implementation of predictive and mechanistic safety capabilities for Neuroscience and Cardiovascular, Renal, and Metabolic (CVRM) therapeutic portfolios.
Role type
Principal / Senior Principal Scientist (Investigative Toxicology)
Builds
Preclinical safety roadmaps for emerging modalities (biologics, gene therapies, cell therapies) and New Approach Methodologies (NAMs)
Domain
Pharmaceutical R&D / Investigative Toxicology / Neuroscience & CVRM
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
mechanistic safety assessment, cellular pathways, organ-level physiology, advanced in vitro models, microphysiological systems (MPS), iPSC technologies, high-content phenotypic assays, multi-omics/transcriptomics, statistical analysis, data visualization
Preferred skills
experience with emerging therapeutic modalities, collaboration with computational biologists, external scientific representation
Technologies
GraphPad Prism, Spotfire, JMP, R, Python
Responsibilities
Serve as primary subject matter expert on discovery and early development project teams; Establish and execute hypothesis-driven preclinical safety roadmaps for novel modalities; Drive strategic identification and validation of next-generation safety assessment capabilities; Partner with predictive toxicology groups to implement human-relevant cellular systems; Represent the group in external industry, academic, and regulatory consortia
Seniority
Principal / Senior Principal, hands-on IC with strategic leadership
