Principal / Senior Principal Scientist- Investigative Toxicology
Core
Drive strategy, development, and implementation of predictive and mechanistic safety capabilities for Neuroscience and Cardiovascular, Renal, and Metabolic (CVRM) therapeutic portfolios using state-of-the-science in vitro and ex vivo approaches.
Role type
Principal / Senior Principal Scientist (Investigative Toxicology)
Builds
Preclinical safety roadmaps for emerging modalities (biologics, gene therapies, cell therapies) and New Approach Methodologies (NAMs)
Domain
Pharmaceutical R&D / Investigative Toxicology / Neuroscience & CVRM
Required skills
Mechanistic toxicology, preclinical safety strategy, emerging therapeutic modalities, microphysiological systems (organ-on-a-chip), iPSC technologies, statistical analysis, data visualization
Preferred skills
Cross-functional leadership, external scientific representation, computational toxicology collaboration
Technologies
GraphPad Prism, Spotfire, JMP, R, Python
Responsibilities
Serve as subject matter expert on discovery/early development project teams; Establish and execute hypothesis-driven preclinical safety roadmaps for novel modalities; Drive validation of next-generation safety assessment capabilities; Partner with predictive modeling groups to implement human-relevant cellular systems; Represent the group in external industry and regulatory consortia
Seniority
Principal / Senior Principal, hands-on IC with strategic leadership