Senior or Principal Scientist of Human Genetics
Core
Drive human-genetics support for CRM discovery and portfolio projects using population-scale biobanks and clinical data to generate decision-relevant evidence for drug development.
Role type
Senior or Principal Scientist (Human Genetics)
Builds
Genetically supported targets, indications, and robust genetics packages for portfolio milestones including Candidate Selection.
Domain
Biopharmaceuticals, Cardio-Renal-Metabolic (CRM) diseases, Statistical Genetics
Deliverable
production ML models | research | client delivery
Required skills
GWAS, PheWAS, fine-mapping, colocalisation, Mendelian randomisation, rare-variant analysis, polygenic risk scores, time-to-event analysis, R, Python, biobank-scale data analysis, disease translation
Preferred skills
AI-assisted tools for genetic analysis workflows, mentoring scientists, setting analytical standards
Technologies
R, Python
Responsibilities
Identify and prioritize genetically supported targets and indications; integrate genetic evidence with molecular QTL, transcriptomic, proteomic, and single-cell data; translate findings into recommendations for therapeutic concept and biomarker decisions; lead cross-functional Human Genetics initiatives; communicate complex evidence to senior stakeholders; set scientific quality standards and establish scalable methods.
Seniority
Senior/Principal, hands-on IC with strategic leadership and mentoring