Senior Principal Scientist (m/w/d)
Core
Lead and execute clinical Quantitative Systems Pharmacology (QSP) modeling projects to drive model-informed decision making across drug development programs.
Role type
Senior Principal Scientist (QSP Modeling)
Builds
Mechanistic models integrating non-clinical, translational, biomarker, and clinical data to support clinical development decisions.
Domain
Biopharmaceuticals / Systems Pharmacology
Deliverable
production ML models
Required skills
QSP modeling, mechanistic modeling, model calibration, sensitivity analysis, statistical methods for clinical data, R, MATLAB/SimBiology, Julia, OSP Suite
Preferred skills
Experience with regulatory authorities, experience with statistical methods for nonclinical data
Technologies
R, MATLAB/SimBiology, Julia, OSP Suite
Responsibilities
Lead and execute clinical QSP modeling projects, develop and qualify fit-for-purpose QSP models, translate biological knowledge into quantitative model structures, define QSP modeling strategies, provide independent advice on complex modeling challenges, provide scientific leadership and guidance, drive innovation and standardization in mechanistic modeling
Seniority
Principal, hands-on IC with strategic leadership
