Chemielaborant / CTA / BTA (m/w/d) – LC-MS/MS und Massenspektrometrie | Biotransformation
Core
Planning and executing drug metabolism and biotransformation studies, including sample preparation and metabolite identification using LC-MS/MS and high-resolution mass spectrometry.
Role type
Senior IC analytical chemist (drug metabolism)
Builds
Analytical data and reports for new chemical entity (NCE) candidates and peptides
Domain
Pharmaceutical R&D / Drug Metabolism
Required skills
LC-MS/MS analysis, sample preparation (protein precipitation, LLE, SPE), in-vitro incubations (microsomes, hepatocytes, S9), metabolite identification, GLP documentation
Preferred skills
Cell culture, drug metabolism knowledge, high-resolution mass spectrometry
Technologies
LC-MS/MS, high-resolution mass spectrometry
Responsibilities
Plan and organize practical laboratory work based on study protocols, perform and evaluate drug metabolism studies, prepare biological samples, develop methods for small organic molecules and peptides, identify and elucidate metabolite structures, document all steps according to GLP standards, collaborate with study leaders on implementation and reporting
