Senior Research Investigator, Pharmacometrics
Core
Develop and implement model-informed drug development (MIDD) plans using pharmacometrics (PMx) models to inform clinical study hypotheses, dose selection, and regulatory assessments for therapeutic agents.
Role type
Senior IC pharmacometrician (MIDD)
Builds
Model-informed drug development plans and regulatory submissions
Domain
Pharmaceutical drug development / Pharmacometrics
Deliverable
production ML models
Required skills
Population pharmacokinetics/pharmacodynamics, exposure-response analysis, model-based meta-analyses, mechanistic modeling (QSP/PBPK), data wrangling, visualization, R, NONMEM, Monolix, Pumas, Matlab, Python, Julia
Preferred skills
Scientific machine learning, agentic workflows, knowledge of current PMx and CP practices
Responsibilities
Specify MIDD components of PMx plans, formulate and execute modeling and data plans, report on formal PMx analyses for CSRs and regulatory submissions, manage vendor PMx analyses, participate in health authority interactions, maintain PMx infrastructure
Seniority
Senior, hands-on IC