Postdoctoral in Structural studies of mitochondrial DNA replication
Core
Determine structures of mitochondrial DNA replication protein complexes using single-particle cryo-EM and combine findings with biochemical analyses to understand molecular mechanisms of replication and disease-associated mutations.
Role type
Postdoctoral researcher in structural biology (mitochondrial DNA replication)
Builds
Structural models of replication complexes and mechanistic insights into mtDNA replication regulation
Domain
Structural biology, biochemistry, mitochondrial genetics
Required skills
single-particle cryo-EM, protein complex preparation, in vitro biochemistry, structural analysis, grid optimization
Preferred skills
cell biology, molecular biology, biochemistry
Technologies
cryo-EM, single-particle analysis
Responsibilities
Prepare and biochemically characterize protein complexes, perform cryo-EM sample preparation and grid optimization, process and analyze cryo-EM data, test mechanistic models with biochemical assays, investigate effects of disease-associated mutations
Seniority
Postdoctoral, independent researcher