Postdoctoral Associate: Nanopore Spectroscopy for Single-Molecule Biodosimetry
Core
Develop nanopore spectroscopy measurements to quantify ionizing-radiation damage to polymers and nucleic acids for biodosimetry applications.
Role type
Postdoctoral Research Associate (Biophysical Metrology)
Builds
Single-molecule measurement approaches connecting molecular damage to absorbed dose and radiation chemistry.
Domain
Biophysics / Radiation Chemistry / Nanotechnology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
experimental design, nanopore spectroscopy, resistive-pulse sensing, polymer/nucleic acid chemistry, data analysis (Python/MATLAB/R), statistical modeling
Preferred skills
electrophysiology, DNA/RNA sample preparation, radiation dosimetry, signal processing, uncertainty quantification
Technologies
nanopores, nanopipettes, resistive-pulse sensing, electrophysiology, spectroscopy, chromatography, electrophoresis
Responsibilities
Design and execute research on measuring ionizing-radiation dose using polymer chain scission reactions; Prepare and characterize standard polymers and nucleic acids for irradiation and measurement; Measure radiation-induced molecular damage using nanopore spectroscopy; Develop and validate dose-response curves as a function of radiation quality; Analyze nanopore signals to quantify fragment-length distributions and dose response; Develop physical, statistical, and computational models linking radiation chemistry to absorbed dose and RBE; Collaborate with NIST teams in nanopore sensing, radiation dosimetry, and radiation biology; Report results through internal and external presentations and peer-reviewed publications
Seniority
Postdoctoral, hands-on research
