PhD Studentship in Rare Kidney Disease (Non-Clinical) Nephronophthisis - Novel Treatments to STOP Disease
Core
Researching novel nonsense read-through drugs to treat Nephronophthisis (NPHP) by characterizing urine-derived renal epithelial cells (URECs) and validating treatments in animal models.
Role type
PhD Researcher (Biosciences/Molecular Biology)
Builds
Preclinical proof-of-concept data and UREC biomarker validation for NPHP therapy.
Domain
Rare kidney disease / Molecular genetics / Drug discovery
Deliverable
Research
Required skills
Human genetics, molecular biology, cell culture (URECs), phenotyping, transcriptional analysis, animal model work
Preferred skills
MRes qualification
Technologies
N/A
Responsibilities
Characterize primary ciliary phenotype in URECs with nonsense mutations, assess response to nonsense read-through compounds, utilize Cep290 animal models to examine in vivo effects.
Seniority
PhD Candidate
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