Senior Scientist, Cardiac Modeling
Core
Develop and apply iPSC-derived cardiomyocyte (iPSC-CM) models to study genetic and molecular underpinnings of cardiovascular disease, generating datasets for ML-driven drug discovery.
Role type
Senior Scientist, Cardiac Disease Biology (Physical AI/Drug Discovery)
Builds
iPSC-CM disease models, functional assays, and scalable experimental platforms for cardiovascular research
Domain
Biotechnology / Cardiovascular Biology / Machine Learning
Deliverable
production ML models | product features
Required skills
iPSC culture and cardiac differentiation, CRISPR genetic editing, high-content imaging, cardiovascular physiology, human genetics (GWAS), experimental design for ML
Preferred skills
3D/engineered heart tissue (EHT) assay development, automated microscopy pipelines, target validation
Technologies
CRISPR, iPSC lines, high-content imaging platforms, automated microscopy
Responsibilities
Lead generation and QC of iPSC lines and cardiomyocyte differentiation; Design and optimize 2D/3D iPSC-CM assays; Build isogenic disease models; Develop functional readouts (contractility, electrophysiology); Partner with ML teams to design experiments and interpret outputs; Mentor junior scientists
Seniority
Senior, hands-on IC with mentorship